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DNA-based programmed

New DNA-based chip can be programmed to solve complex math problems

The field of DNA computing has evolved by leaps and bounds since it was first proposed nearly 30 years ago. But most DNA computing processes are still performed manually, with reactants being added step-by-step to the reaction by hand. Now, finally, scientists at Incheon National University, Korea have found a way to automate DNA calculations…

The field of DNA computing has evolved by leaps and bounds since it was first proposed nearly 30 years ago. But most DNA computing processes are still performed manually, with reactants being added step-by-step to the reaction by hand. Now, finally, scientists at Incheon National University, Korea have found a way to automate DNA calculations by developing a unique chip that can be controlled by a personal computer.

The term ‘DNA’ immediately calls to mind the double-stranded helix that contains all our genetic information. But the individual units of its two strands are pairs of molecules bonded with each other in a selective, complementary fashion. Turns out, one can take advantage of this pairing property to perform complex mathematical calculations, and this forms the basis of DNA computing.

Since DNA has only two strands, performing even a simple calculation requires multiple chemical reactions using different sets of DNA. In most existing research, the DNA for each reaction are added manually, one by one, into a single reaction tube, which makes the process very cumbersome. Microfluidic chips, which consist of narrow channels etched onto a material like plastic, offer a way to automate the process. But despite their promise, the use of microfluidic chips for DNA computing remains underexplored.

In a recent article — made available online in ACS Nano on 7 July 2021 and published in Volume 15 Issue 7 of the journal on 27 July 2021 — a team of scientists from Incheon National University (INU), Korea, present a programmable DNA-based microfluidic chip that can be controlled by a personal computer to perform DNA calculations. “Our hope is that DNA-based CPUs will replace electronic CPUs in the future because they consume less power, which will help with global warming. DNA-based CPUs also provide a platform for complex calculations like deep learning solutions and mathematical modelling,” says Dr. Youngjun Song f

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